Open AccessCOMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT “ AMMI VISNAGA AND CIMETIDINE ON THE VOLUME AND ACIDITY OF STIMULATED GASTRIC SECRETION IN FASTING RABBITS.
Author(s) -
Muhammad Saeed Jan
Publication year - 1969
Publication title -
journal of saidu medical college
Language(s) - English
Resource type - Journals
ISSN - 1819-4583
DOI - 10.52206/jsmc.2012.2.2.165-168
Subject(s) - cimetidine , ammi , carbachol , medicine , traditional medicine , pharmacology , chemistry , stimulation , biochemistry , gene–environment interaction , genotype , gene
Background: Peptic ulcer is mostly produced due to the over production of gastric acid. This study wasundertaken to find out the effects of extract from medicinal plant “ Ammi visnaga” (which containsdocumented natural Calcium channel blocker) and Cimetidine on volume and acidity of Carbachol inducedgastric section. Their effects were also compared to find out any difference in their efficacy.METHODS: Thirty rabbits of local breed, weighing 1-1 ,5kg were used. The animals were kept on fastingfor 48 hours, after which the pylorus of each animal was ligated. Cimetidine 2.5 mg/kg, Ammi visnaga, 500mg/kg and Carbachol 600g/kg body weight were administered intraperitoneally.Results: It was found that Cimetidine reduced the volume, free and total acidity of gastric secretion, whichwere highly significant when compared with Carbachol ( P<0.001). The extract also had the same effects.When the difference of mean for Cimetidine was compared with that of extract, all these differences werefound non-significant indicating that the extract has similar effect as that of Cimetidine on all parametersincluded in the study.Conclusion: The extract from the fruits of Ammi visnaga therefore, be used effectively in the treatment ofpeptic ulcer and all other conditions like angina, myocardial infarction and hypertension which requirecalcium channel blockers for their treatment.Key words: Ammi visnaga, Zollinger-Ellison (Z.E) syndrome