Open AccessAn investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity
Author(s) -
Gülru ESEN>,
Miraç Uçkun,
Ahmet Kağan Özkaya,
Ertan Yoloğlu,
Ebru Annaç,
Hıdır Pekmez,
Seda Uludağ
Publication year - 2021
Publication title -
deneysel ve klinik tıp dergisi/journal of experimental and clinical medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 3
eISSN - 1309-4483
pISSN - 1309-5129
DOI - 10.52142/omujecm.38.2.5
Subject(s) - acrylamide , neurotoxicity , glutathione , chemistry , malondialdehyde , antioxidant , food science , carrot juice , toxicity , biochemistry , enzyme , organic chemistry , copolymer , polymer
Acrylamide is an organic compound that is known to have neurotoxic influences. People have high exposure to its impacts because of its extensive uses in the industrial fields and its occurrence in foods. This situation has induced the scientific word to identify naturel components that may eliminate these neurotoxic effects. In this experimental study the influence of black carrot juice containing bioavailable flavonoids was researched on acrylamide neurotoxicity. In the study, laboratory rats were divided in to four groups. Group 1 rats were the control group. While the rats in Group 2 were administered acrylamide substance, the rats in Group 3 were supplemented with black carrot juice + acrylamide, and the rats in Group 4 were given black carrots juice only. At the experiment’s end, biochemical, histopathological, and histomorphometry analysis were performed on exanguned rats. Significant histopathological degenerations were observed in the acrylamide treated group. Despite a volumetric degrease in all brain regions examined histomorphometrically, this decrease was not statistically significant. The malondialdehyde and Glutathione S-transferase levels of the acrylamide group showed a significant increase compared to the control group. The glutathione, carboxylesterase and acetylcholinesterase levels were observed to increase in the acrylamide and black carrot applied group, compared to the acrylamide group. This study’s findings have revealed the black carrot’s healing effects on acrylamide neurotoxicity.