Open AccessEvaluation of pai-1 polymorphisms in central and peripheral thromboembolies
Author(s) -
Özge Arıcı Düz,
Oktay Ölmüşçelik,
Ali Gemici,
Özlem Saatçi Sancaktepe
Publication year - 2021
Publication title -
deneysel ve klinik tıp dergisi/journal of experimental and clinical medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 3
eISSN - 1309-4483
pISSN - 1309-5129
DOI - 10.52142/omujecm.38.2.20
Subject(s) - medicine , methylenetetrahydrofolate reductase , venous thromboembolism , prothrombin g20210a , peripheral , factor v leiden , thrombosis , thrombus , etiology , risk factor , gastroenterology , disease , venous thrombosis , allele , genetics , biology , gene
Thromboembolism is a clinical finding that occurs due to thrombus; formed in the vascular system and has various etiological factors. It can be classified as central and peripheral thromboembolism. Our objective in this study is to explore genetic risk factors in central and peripheral thromboembolism and reveal the differences. 342 thromboembolism patients were retrospectively included to the study between January 2016 and December 2019. Demographic characteristics, risk factors for thromboembolism and genetic mutations in central and peripheral thromboembolism groups were overviewed. The genetic mutations evaluated in patients were Factor V Leiden G1691A, Factor V HR1299R, Factor II (Prothrombin) G20210A, MTHFR (Methylenetetrahydrofolate reductase) C677T, MTHFR A1298C, PAI 4G/5G. Within the scope of the study, genetic analyzes of 106 patients were reached and included in the study. Seventy-two central thromboembolism (69.8%), 34 (31.2%) peripheral thromboembolisms were detected. Sixty-three of the central thromboembolisms were from arterial and nine were from venous origin. There was no significant difference between age, gender and risk factors of central thromboembolism and peripheral thromboembolism patients (p˃0.05), but smoking was more common in central thromboembolism patients (p: 0.041). 4G/5G polymorphism was observed more frequently in patients with central thromboembolism (p: 0.039). Thromboembolism is a multifactorial disease, PAI-1 4G/5G polymorphism is a medium risk factor for thromboembolism. We conclude that PAI-1 4G/5G polymorphism is more frequent in central thromboembolism than peripheral thromboembolism and its evaluation can give more information about the thromboembolic risk analyze.