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Estudio histológico del desarrollo del cerebelo
Author(s) -
E. García Jarabo,
A. Rodríguez Serrano
Publication year - 2017
Publication title -
revista complutense de ciencias veterinarias
Language(s) - Spanish
Resource type - Journals
ISSN - 1988-2688
DOI - 10.5209/rccv.55496
Subject(s) - cerebellum , dorsum , hindbrain , anatomy , granule cell , granule (geology) , granular layer , biology , lamination , neuroscience , embryo , chemistry , microbiology and biotechnology , layer (electronics) , central nervous system , paleontology , dentate gyrus , organic chemistry
We study the histological cerebellar development in rats and we compared it chronologically to humans. The cerebellum derives from the hindbrain, and its origin occurs in Er15d/Eh8w (embryo days/weeks). Sources of neurons in the cerebellum are: 1) subventricular region where precursors of Purkinje neurons migrate radially towards to the dorsal surface of the cerebellar anlage, where they organize in several layers (Er18d/Eh13w). Later, Purkinje neurons arranged in a unique layer (Pr6d/Eh30w; Postnatal); 2)  rostral part of the rhombic lip, from which granule cells precursors migrate tangentially to constitute the external granular layer (EGL) located next to the dorsal area of the cerebellar anlage (Er17d/Eh10w). EGL granule cells migrate to a deeper possition, overcoming the Purkinje layer to form the internal granule layer (IGL) (Pr0-1d/Eh20w). Subsequently EGL disappears (Pr20d/Ph7months), establishing a single granular layer. The primary lamination starts in Er20-21d/Eh12w and secondary lamination in Pr0-1d/Eh15w.Se estudia histológicamente el desarrollo del cerebelo en la rata y se compara cronológicamente con el humano. El cerebelo deriva del rombencéfalo y su esbozo se establece en Er15d/Eh8s (Embrión días/semanas). La fuente de neuronas en el cerebelo es: 1) región subventricular, desde donde migran radialmente los precursores de las neuronas de Purkinje hacia la parte más dorsal del esbozo cerebeloso, formando múltiples capas (Er18d/Eh13s), para más adelante organizarse en una sola hilera (Pr6d/Eh30s; Postnatal); 2) parte rostral del labio rómbico, a partir del cual y por migración tangencial hacia la zona dorsal, se genera la capa granular externa (EGL) (Er17d/Eh10s). Desde la EGL, los granos migran hacia la profundidad sobrepasando los somas de Purkinje, para constituir la capa granular interna (IGL) (Pr0-1d/Eh20s). Posteriormente la EGL desaparece (Pr20d/Ph7meses), estableciéndose una única capa granular. La laminación primaria se inicia en Er20-21d/Eh12s y la secundaria en Pr0-1d/Eh15s

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