Open AccessTHE EFFECT OF MAGNETO-LASER THERAPY ON THE PHENOTYPE OF BASOPHILS IN CHILDREN WITH ATOPIC ASTHMA
Author(s) -
Elena Asiryn,
P. Novikov,
Volha Matsiushchanka,
Nadiezhda Titova,
Lukas Vaidelys,
Greta Griciūnaitė
Publication year - 2019
Publication title -
sveikatos mokslai
Language(s) - English
Resource type - Journals
eISSN - 2335-867X
pISSN - 1392-6373
DOI - 10.5200/sm-hs.2019.014
Subject(s) - immunoglobulin e , medicine , asthma , basophil , immunology , group b , cd63 , group a , basophil activation , gastroenterology , antibody , biochemistry , gene , microrna , chemistry , microvesicles
In recent years there has been growing evidence to suggest a major role of basophils alongside eosinophils and mast cells in allergic inflammation.The aim of this study was to analyze the dynamics of the basophil phenotypes after the use of magneto-la-ser therapy in children with atopic bronchial asthma.Materials and methods. A total of 66 children with mild persistent atopic bronchial asthma (aged 6 to 18 years old) were examined. Group A included 34 children who received magneto-laser therapy together with basic asthma treatment (low dose of inhaled corticosteroids). Group B included 32 children who received only basic asthma therapy. The level of CD203с + , CD203с + CD63 + , CD203с + IgE + basophils was determined in peripheral blood in the beginning of the study, after 2 weeks and after 3 months.Results. A statistically significant decrease in the absolute levels of CD203с+CD63+ and CD203с + IgE + basophils and in the relative level of CD203с + IgE + among all CD203с + basophils was determined in group A after magneto-laser therapy. The comparison of group A and group B indices revealed a significant difference between the relative level of CD203с + IgE + basophils after 12-15 days from the beginning of the study. This indicator was significantly lower in group A than in group B (p<0.05). The absolute level of CD203с + IgE + basophils was significantly lower in group A in comparison with group B after 82-90 days (p<0.05).Conclusions. Magneto-laser therapy can change the phenotype of basophils in children with atopic bronchial asthma, causing suppression of proallergic pa-rameters. Considering these results there is reason to believe, that it is possible to use this method as an additional immunocorrective treatment in patients with basophilic phenotype of atopic asthma.