Open AccessGender, Depression and Zincum metallicum
Author(s) -
Silvio Leite Monteiro da Silva,
Maria Martha Bernardi,
Leoni Villano Bonamin
Publication year - 2021
Publication title -
international journal of high dilution research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 9
ISSN - 1982-6206
DOI - 10.51910/ijhdr.v15i4.835
Subject(s) - homeopathy , tail suspension test , medicine , offspring , pregnancy , depression (economics) , traditional medicine , physiology , behavioural despair test , biology , genetics , alternative medicine , macroeconomics , pathology , hippocampus , economics , antidepressant
Background: Depression is a hot topic for research including for the homeopathy community. Laboratory models for human diseases offer the possibility to evaluate depression-like behavior in mice by the tail suspension test (TST), such as the challenge of mothers with induced inflammation by lipopolysaccharide (LPS) during gestation. Moreover, it is known that gender influences depression prevalence and treatment evolution as well in a homeopathic approach. Aims: Verify if the treatment of LPS-challenged pregnant mice with homeopathic Zincum metallicum would change the depression-like behavior of the offspring according to the gender. Methodology: the procedures with animals were previously approved according to local and international law (CEUA-UNIP protocol 156-13). Pregnant randomized BALB/c mice were treated in blind with Zincum metallicum 200c, 30c, 5c and Lactose 5c as control. The treatment lasted 31 days: 21 days from the mating day to the delivery plus ten days of lactating. At the 9.5 days of pregnancy, mothers were challenged or not with 100 microgram/Kg of LPS IP. The pups were separated by sex and mother treatment. The tail suspension test was performed to all pups after they grow up to adulthood (2 months old). Results: The treatment influenced the TST according to gender, but not according to mother’s LPS exposition. Female mice born from mothers treated with 200c potency showed reduction in the immobility time in relation to the control (p-value