Open AccessEffect of Zincum metallicum and LPS treatments on femoral bone density in pregnant mice
Author(s) -
Silvio Leite Monteiro da Silva,
Maristela Dutra Correa,
Claudio Costa,
Vanessa Gallego Arias Pecorari,
Emiko Saito Arita,
Maria Martha Bernardi,
Carla Holandino,
Leoni Villano Bonamin
Publication year - 2021
Publication title -
international journal of high dilution research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 9
ISSN - 1982-6206
DOI - 10.51910/ijhdr.v14i2.798
Subject(s) - serial dilution , lipopolysaccharide , bone remodeling , zinc , andrology , staphylococcus aureus , medicine , chemistry , bacteria , biology , endocrinology , pathology , alternative medicine , organic chemistry , genetics
Background: The simulated bacterial infection is a classical experimental model, by the injection of purified gram negative bacteria wall lipopolysaccharide (LPS) which produces effects similar to real infection, but without presence of the microorganism. The LPS is a stress factor as during the pregnancy and delivery, and pilot experiments have shown that ultra-high dilutions (UHD) may have a beneficial role in reducing the LPS stress. Zincum metallicum (Zm) has a potential to influence several physiological aspects of a living organism. It was chosen by a team of researchers from GIRI, to explore the effect of Zm on various experimental model (Zincum project).
The optical density is a radiographic method for the measurement of the amount of hard bone tissue, and is an accessible, simple and non-invasive method. It is hypothesized that UHD Zm may influence the Zinc metabolism, therefore, bone tissues were collected to evaluate the zinc concentration.