Open AccessFarmakokinetika dan Bioavailability Senyawa Golongan Santon Revew Komprehensif
Author(s) -
Meri Susanti
Publication year - 2019
Publication title -
jurnal penelitian farmasi indonesia/jurnal penelitian farmasi indonesia
Language(s) - English
Resource type - Journals
eISSN - 2656-3614
pISSN - 2302-187X
DOI - 10.51887/jpfi.v8i2.780
Subject(s) - bioavailability , adme , pharmacokinetics , pharmacology , traditional medicine , chemistry , xanthone , distribution (mathematics) , medicine , stereochemistry , mathematics , mathematical analysis
The use of herbs for treating various ailment dates back several centuries. Evidence-based verification of the efficacy of Herbal medicines is still frequently lacking. Of particular interest is the question of bioavailability to assess to what degree and how fast compounds are absorbed after administration of herbal. Of further interest is the elucidation of metabolic pathways, and the assessment of elimination routes and their kinetics. These data become an important issue to link data from pharmacological assays and clinical effects. A better understanding of the pharmacokinetics and bioavailability of phytopharmaceuticals can also help in designing rational dosage regimens. To provide provide a detailed picture on ADME parameters (absorption, distribution, metabolism, and excretion) of some xanthone active compound, this article reviews the pharmacokinetic profile of 7 xanthones bioactive compound from the year 2009 onward.