Open AccessEFFECTS OF BERENIL ON THE PATHOGENESIS OF TRYPANOSOMIASIS IN Trypanosoma brucei INFECTED RATS
Author(s) -
J. S. Rabo,
A. B. Wakil,
H.C.C. Maduka .
Publication year - 2021
Publication title -
nigerian journal of animal production
Language(s) - English
Resource type - Journals
ISSN - 0331-2062
DOI - 10.51791/njap.v21i1.1165
Subject(s) - choroid plexus , biology , trypanosomiasis , pathogenesis , trypanosoma , physiology , trypanosoma brucei , strain (injury) , virology , immunology , central nervous system , endocrinology , anatomy , gene , biochemistry
Ten Albino rats were each infected intraperitoneally with 0.5 million Trypanosoma strain 8/18 organisms. Cerebral lesions were absent in all rats and mice injected with brain tissue and choroid plexus homogenates from group A rats were aparasitaemic over anobservation period of 30 days. However, infected rats developed intermittent (parasitaemia, lost weight progressively and became anaemic with death intervening in one case. We conclude that T. bricci strain 8/18 infection in rats produces moderate to severe disease which may lead to death; but the organism is is not pushed across the blood-brainbarrier by berenil treatment in the acute stage.