Open AccessCOMPARISON OF EFFICACY OF NEPAFENAC 0.3% AND NEPAFENAC 0.1% TO PREVENT AND CONTROL POSTOPERATIVE PAIN AND CONJUNCTIVAL REDNESS AFTER CATARACT SURGERY: A RANDOMIZED CONTROL TRIAL
Author(s) -
S. Jabeen,
Zeeshan Hameed,
Bazla Batool,
Irfan Malik,
Aamna Jabran,
Abdullah Younas
Publication year - 2022
Publication title -
pakistan postgraduate medical institute
Language(s) - English
Resource type - Journals
ISSN - 2710-1924
DOI - 10.51642/ppmj.v32i03.456
Subject(s) - medicine , randomized controlled trial , surgery , cataract surgery , group b , pain score , postoperative pain , ophthalmology , anesthesia
Purpose: To compare the efficacy of nepafenac 0.3% with nepafenac 0.1% to control postoperative pain and conjunctival redness after cataract surgery.
Study Design: Randomized control trial
Place and Duration: Ophthalmology Department, DHQ Teaching Hospital, Gujranwala from November 2020 to January 2021.
Materials and Methods: A prospective review of 70 patients operated for age-related cataract was done. Patients were divided into two equal groups. Group A patients were given Ilevro eye drops (nepafenac 0.3%) once a day and group B patients were instilled Nevanac eye drops (nepafenac 0.1%) thrice a day. All patients were scored for ocular pain and conjunctival redness on basis of pre-defined scales on one day before surgery and on 1st, 7th and 14th postoperative day. Results from both groups were analyzed and compared using SPSS v 25.0.
Results: Out of 70 patients, 35 were put in group A and 35 into group B. Overall 37 (52.8%) patients were male and 33 (47.2%) were female. Patients above 40 years of age were 33 (94.3%) in group A and 35 (100%) in group B. Patients having pain score ≥5 were 30 (85.7%) in group A and 25 (71.4%) in group B on 1st postoperative day, with ≥3 were 1 (2.8%) in group A and 33 (94.2%) in group B at 7th postoperative day and zero on 14th postoperative day. Patients with conjunctival redness ≥2 were 31 (88.6%) in group A and 29 (82.9%) in group B on 1st postoperative day, with ≥1 were 18 (51.3%) in group A and 28 (79.9%) in group B on 7th postoperative day while four (11.4%) in group A and one (2.8%) in group B on 14th postoperative day. Conclusion: Effect of once daily nepafenac 0.3% on postoperative pain and conjunctival redness was found to be sub-rated against thrice daily nepafenac 0.1% on 1st postoperative day. However, this effect became equal and then slightly superior to that of nepafenac 0.1% on 7th and 14th postoperative days.
Key Words: Cataract Surgery, Nepafenac, Postoperative Pain, Conjunctival Redness