Open AccessFREQUENCY AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PSEUDOMONAS AERUGONISA CLINICAL ISOLATES AT A LARGE TEACHING HOSPITAL IN LAHORE, PAKISTAN
Author(s) -
Sarmad Zahoor,
Hafiz Mudabbar Mahboob,
Hina Bukhari,
Asad Ali,
Hafiz Muhammad Sajid Jehangir,
A. Siddiqui
Publication year - 2021
Publication title -
pakistan postgraduate medical institute
Language(s) - English
Resource type - Journals
ISSN - 2710-1924
DOI - 10.51642/ppmj.v31i04.366
Subject(s) - amikacin , ceftazidime , ciprofloxacin , medicine , ceftriaxone , antibiotics , antibiotic sensitivity , microbiology and biotechnology , antibiotic resistance , pseudomonas aeruginosa , biology , bacteria , genetics
Psudomonas is a notorious nosocomial aerobic bacillus mostly involved in causing pneumonia, surgical site infection and urinary tract infection. Resistance of pseudomonas has increased in recent past and has posed a serious health challenge to public health. We aimed to investigate resistance pattern of pseudomonas at a large teaching hospital of Lahore.
Materials and Methods: This was a Single Centre Observational Cross-Sectional Retrospective Study conducted at Mayo hospital Lahore which included clinical isolates of pseudomonas isolated during 2019 obeying inclusion and exclusion criteria. Organism was identified with standard protocols and was tested for susceptibility to various antibiotics as per CSLI guidelines. Data was analyzed with SPSS 23.
Results: Of 1506 isolates, the most sensitive drug was collistin (100%). Relatively higher sensitivity was reported for imipenum (94.48%) followed by amikacin (91.96%). Least sensitive of all the tested drugs was ceftriaxone (12.48%) followed by tazobactum/pipperacillin (33.3%). Ceftazidime (74%), gentamycin (70.1%) and ciprofloxacin (65.6%) showed intermediate level of sensitivity in our study.
Conclusion: Collistin , Imipenum and amikacin are effective drugs against pseudomonas. However, the resistance of the bug is increasing which warns for judicious use of antibiotics.