Open AccessAn Effect Virgin Coconut Oil Oral And Topical On Volume Decrease Of Foot Edema Of Male Wistar Flows Induced By –Caragenan
Author(s) -
Dzil Fikri,
Ermi Girsang,
Ali Napiah Nasution,
Linda Chiuman
Publication year - 2022
Publication title -
international journal of health and pharmaceutical
Language(s) - English
Resource type - Journals
ISSN - 2808-845X
DOI - 10.51601/ijhp.v2i1.38
Subject(s) - coconut oil , carrageenan , flavonoid , edema , chemistry , anti inflammatory , pharmacology , food science , medicine , biochemistry , antioxidant
Virgin Coconut Oil(VCO) is virgin coconut oil that is made enzymatically. The content of saturated fatty acids and flavonoid compounds in VCO can be used as an anti-inflammatory drug. This study aims to determine the activity of VCO as an anti-inflammatory. Anti-inflammatory activity was tested using the method of calculating the percentage of inflammation inhibition in white rat paws induced by intraplantar 1% carrageenan solution. The decrease in edema in the rat's feet was measured using a plethysmometer for 360 minutes. The results showed that VCO at a dose of 0.4 ml/200 g BW and 0.8 ml/200 g BW gave anti-inflammatory activity with the percentage of inflammation inhibition of 64.34 ± 9.90 and 52.66 ± 8, respectively. 94. The anti-inflammatory activity of VCO at a dose of 0.4 ml/ 200 g BW and a dose of 0.