Open AccessNEW PHARMACOLOGICALLY ACTIVE COMPOUNDS BASED ON 5-HYDROXY-7-METHOXY-2-PHENYLCHROMAN-4-ONE
Author(s) -
G.M. Baisarov,
С. М. Адекенов
Publication year - 2021
Publication title -
himičeskij žurnal kazahstana
Language(s) - English
Resource type - Journals
eISSN - 2710-1185
pISSN - 1813-1107
DOI - 10.51580/2021-1/2710-1185.44
Subject(s) - chalcone , chemistry , alkylation , potassium carbonate , acetone , alkoxy group , in vivo , potassium , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , alkyl , catalysis , microbiology and biotechnology , biology
The reaction of 5-hydroxy-7-methoxy-2-phenylchroman-4-one with dibromoalkanes in acetone in the presence of potassium carbonate proceeds according to the Michael’s retro-reaction O-alkylation and leads to the formation of the corresponding 2-(bromo-alkoxy) chalcones. The structure of the synthesized compounds was confirmed by IR-, 1H- and 13C-NMR spectroscopy. The cytotoxic, hepatoprotective and anti-inflammatory effects of chalcone derivatives (2-3) were studied for the first time in vitro and in vivo.