Open AccessFecal secretory immunoglobulin a, human ß defensin-2, and calprotectin levels in preterm neonates who consumes breast milk only, formula milk only, and combination
Author(s) -
Eko Sulistijono,
Putri Primawardani,
Rusdian Niati Ningsih,
Bernardinus P.A. Pradipta
Publication year - 2022
Publication title -
pediatrics sciences journal
Language(s) - English
Resource type - Journals
eISSN - 2722-1474
pISSN - 2722-0427
DOI - 10.51559/pedscij.v1i2.16
Subject(s) - calprotectin , feces , breast milk , medicine , antibody , immunoglobulin a , breast feeding , gastroenterology , human breast milk , immunology , immunoglobulin g , biology , microbiology and biotechnology , pediatrics , biochemistry , inflammatory bowel disease , disease
Background: Secretory immunoglobulin A, human ß-defensin2 and calprotectin play an essential role in digestive system defense. This study aims to assess fecal SIgA, hBD-2, and calprotectin in preterm neonates (as inflammation marker) with different feeding patterns.
Method: This study was cohort designed included 39 preterm neonates, which were categorized into breast milk only, formula milk only, and combination. Fecal SIgA, hBD-2, and calprotectin measured by ELISA.
Results: Fecal SIga in the breast milk only group were significantly higher (p<0.005). Fecal HBD-2 and calprotectin in the formula milk only group were highest but not significantly different (p=0.463) with the combination group.
Conclusion: Fecal SIgA levels that consumed breast milk only were significantly higher. Fecal HBD-2 and calprotectin levels that consumed formula milk only were highest but not significantly different from the combination group.