Open AccessMolecular genetic markers of the risk of tension-type headache and migraine chronization development
Author(s) -
С. А. Костюк,
O. S. Poluyan,
M V Simirski,
I P Marjenko
Publication year - 2021
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2021-18-2-21
Subject(s) - genotype , allele , polymorphism (computer science) , genetics , migraine , medicine , gene , gene polymorphism , biology , endocrinology
Objective: to identify the molecular genetic criteria of the risk of tension-type headache and migraine chronization development. Materials and methods.The detection of the results for the determination of allelic variants was carried out by means of horizontal electrophoresis using a molecular weight marker. The determination of the genotypes of the polymorphic variants of genes was carried out using high resolution melting PCR analysis. Results.Based on the performed molecular genetic studies, it has been established that the statistically signicant (p < 0.05) risk factors of tension-type headache chronization are: the identication of the A-allele and AA-genotype of the DBH3 polymorphism of the dopamine-beta-hydroxylase gene DBH , as well as the identication of the G-allele and the GG-genotype of the Intron3SNP polymorphism of the preprotachykinin gene TAC1 . It has been found that the statistically signicant (p < 0.05) risk factors of migraine chronization are: the identication of the A-allele, GA- and AA-genotypes of the G29A polymorphism of the serotonin transporter gene SLC6A4 , as well as the identication of the G-allele and the GG-genotype of the rs7793277 polymorphism of the preprotachykinin gene TAC1.Conclusion. The detection of these polymorphisms of the dopamine and preprotachykinin genes in the blood serum increases the risk of tension headache chronization by 1.395–1.991 times; the risk of migraine chronization by 1.235–1.395 times.