Open AccessCorrelation of the magnetic resonance imaging apparent diffusion coefficient with the count of cellularity in the histological material in different morphological types of lymphomas
Author(s) -
С. А. Хоружик,
О. Р. Анискевич,
E. Zhavrid
Publication year - 2021
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2021-18-2-15
Subject(s) - lymphoma , medicine , magnetic resonance imaging , pathology , effective diffusion coefficient , diffusion mri , biopsy , lesion , correlation , mantle cell lymphoma , radiology , nuclear medicine , geometry , mathematics
Objective: to evaluate the correlation between the values of the magnetic resonance imaging (MRI) apparent diffusion coefcient (ADC) and the count of cellularity in histological material and to establish a relationship between the cellular structure and the prognostic properties of MRI with diffusion-weighted imaging (MRIDWI) in various morphological types of lymphomas. Materials and methods. 101 patients with morphologically veried lymphoma (Hodgkin lymphoma (HL) — 52 patients, non-Hodgkin lymphomas (NHL) — 49) underwent whole body MRI-DWI before treatment and ADC measurement in the target lesion. An excisional biopsy of the lesion was performed from the same anatomical area and the count of cellularity in the histological material was determined. Results. In HL, aggressive NHL and diffuse large B-cell lymphoma (DLBCL), ADC is statistically signicantly higher, and cellularity is lower than in indolent NHL and cells of the mantle zone of NHL. We have found an inverse correlation between the values of ADC and cellularity in aggressive NHL (ρ = -0.47, p = 0.005) and DLBCL (ρ = -0.48, p = 0.006). Conclusion. ADC values depend on the cellular structure of the lymphomas. The correlation of ADC and cellularity values of various morphological types of lymphomas allows explaining the prognostic properties of ADC.