Open AccessEffect of the food additive E407a on E-cadherin expression in the small intestine
Author(s) -
Anton Tkachenko,
Г. И. Губина-Вакулик,
Anna V. Polikarpova,
Anatolii Onishchenko
Publication year - 2021
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2021-18-2-14
Subject(s) - cadherin , stroma , ingestion , immunohistochemistry , epithelium , small intestine , biology , medicine , chemistry , endocrinology , pathology , biochemistry , cell
Objective: to assess the features of the expression of the epithelial marker E-cadherin in the epithelial layer and stroma of the small intestinal mucous membrane after the administration of the food additive E407a. Materials and methods. E-cadherin expression was studied by the immunohistochemical method in 8 WAG rats receiving daily the food additive E407a orally for a period of 2 weeks in the amount of 140 mg per kg of body weight, and 8 control animals. Results. It has been found that the administration of E407a leads to reduced E-cadherin expression in intestinal epithelial cells (0.037 ± 0.004 U versus 0.129 ± 0.021 U in the control group, p < 0.0001) per unit of area (250 × 250 micron). Conclusion. Ingestion of the food additive E407a leads to a change in the expression patterns of the epithelial marker E-cadherin, which may contribute to the disruption of the intestinal epithelial barrier.