Open AccessDiagnostic value of cystatin C for the early diagnosis of diabetic nephropathy
Author(s) -
О. Н. Василькова,
И. Ю. Пчелин,
Е. П. Науменко,
Я. А. Боровец,
Ю. И. Ярец,
Л. Е. Коротаева,
И. А. Васюхина,
Т. В. Мохорт
Publication year - 2021
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2021-18-2-12
Subject(s) - cystatin c , medicine , diabetic nephropathy , renal function , creatinine , albuminuria , diabetes mellitus , urology , nephropathy , cystatin , gastroenterology , endocrinology
Objective: to assess the clinical signicance of cystatin C in the early diagnosis of diabetic nephropathy. Materials and methods. We examined 449 patients with type 1 and type 2 diabetes mellitusolder than 25 years. The laboratory examination of the patients included the measurement of cystatin, creatinine in the blood serum, GFR calculation according to the CKD-EPI equation, and the determination of albuminuria levels. Results. The role of cystatin C as a reliable marker of diabetic nephropathy has been demonstrated: the level of cystatin C ≥ 0.72 mg/L with sensitivity of 90.8 %, specicity of 88.9 %, was associated with a decline of renal function in the diabetic patients (ROC AUC = 0.951). Conclusion. The determination of the level of cystatin C, alone or in conjunction with creatinine, will help to more accurately diagnose GFR and assess the risk of mortality and renal complications in patients with diabetes mellitus.