Open AccessThe Role of the Hepatic Tissue Remodeling Regulators MMP-9 and TIMP-1 in the Progression of Liver Cirrhosis
Author(s) -
А. Г. Скуратов,
А. Н. Лызиков,
Е. В. Воропаев,
О. В. Осипкина,
Д. В. Терешков,
Н. М. Голубых,
M. N. Yatsuk,
А. Н. Кондрачук,
А. Е. Козлов
Publication year - 2019
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2019-16-4-18
Subject(s) - cirrhosis , medicine , matrix metalloproteinase , chronic hepatitis , fibrosis , gastroenterology , extracellular matrix , viral hepatitis , pathology , immunology , virus , biology , microbiology and biotechnology
Objective: to study the level of the hepatic tissue remodeling regulators MMP-9 and TIMP-1 in the blood of patients with the progression of chronic diffuse liver diseases. Material and methods. The object of the study was 80 patients with chronic diffuse liver diseases (chronic hepatitis and cirrhosis). The concentration of MMP-9 and TIMP-1 in the blood of the patients was determined by enzymelinked immunosorbent assay (ELISA). Results: As chronic diffuse liver diseases progressed, a statistically significant decrease in the level of MMP-9 in the blood of the patients was revealed, which was reflected in the decreased intensity of the extracellular matrix resorption processes and transformation of chronic hepatitis into liver cirrhosis. The activity of TIMP-1 which suppressed the fibrolytic effects of MMP-9, was statistically significantly higher in the viral etiology of liver cirrhosis, which probably led to more rapid progression of liver fibrosis associated with the presence of hepatitis C and В viruses.