Open AccessThe Morphological Assessment of Rats` Liver after the Introduction of the Nucleoside Reverse Transcriptase Inhibitor of Azidothymidine
Author(s) -
М. Н. Курбат,
Р. И. Кравчук,
O. B. Ostrovskaya
Publication year - 2019
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2019-16-1-12
Subject(s) - hepatocyte , ultrastructure , mitochondrion , nucleoside , reverse transcriptase , drug , nucleoside reverse transcriptase inhibitor , pharmacology , reverse transcriptase inhibitor , biology , pathology , chemistry , medicine , biochemistry , rna , in vitro , gene
Objective: to study the microscopic and ultrastructural changes in the liver of rats exposed to AZT. Material and methods. The histological and electron microscopic examination of the liver samples with mitochondrial morphometry has been performed. Results . The 7-day administration of AZT does not cause any significant structural changes in the liver. The exposure to the drug for 21 days leads to the development of moderate inflammatory and degenerative processes in the liver, including changes in the structure of hepatocyte mitochondria. Conclusion. One of the pathogenetic mechanisms of the hepatotoxic effect of AZT is its impact on the structural and functional properties of hepatocyte mitochondria.