Open AccessMorphologic and Morphometric Parameters of the Liver Tissue of Laboratory Animals After Modeling of Chronic Stress
Author(s) -
Alexander Litvinenko,
Д. А. Зиновкин,
Т. С. Угольник
Publication year - 2018
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2018-15-4-11
Subject(s) - chronic stress , liver tissue , pathology , medicine , biology
Objective: to study changes in the morphologic and morphometric parameters of the liver tissue in male Wistar rats under chronic Ortiz stress. Material and methods. The study was conducted on 50 male Vistor rats. The experimental group of the animals was subjected to 10-day chronic stress by Ortiz. The morphologic and morphometric parameters of the liver tissue of the animals exposed to chronic stress were studied. Results. The morphologic changes in the liver of the animals which had sustained chronic stress were characterized by impaired blood circulation and degenerative changes of hepatocytes. At the same time, a statistically significant increase in the percentage of binuclear hepatocytes (p = 0.046) and functional cariocellular index (p = 0.03) was found. Conclusion. The effect of chronic stress leads to a change in the morphologic and morphometric parameters of the liver tissue with activation of reparative processes.