Open AccessStructural diversity of erythrocytes in patients with hereditary spherocytosis
Author(s) -
М. Н. Стародубцева,
Е. Ф. Мицура,
И. А. Челнокова,
А. Н. Кондрачук,
N.I. Yegorenkov
Publication year - 2018
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2018-15-2-22
Subject(s) - hereditary spherocytosis , echinocyte , spectrin , spherocytosis , cytoskeleton , red blood cell , biology , biophysics , chemistry , microbiology and biotechnology , cell , genetics , biochemistry , immunology , splenectomy , spleen
Objective: to study the shape of erythrocytes and structure of their surface layer including the membrane and cytoskeleton (actin-spectrin network) in child patients with hereditary spherocytosis. Material and methods. The methods of optic and atomic-force microscopy were used in the study. Results. A variety of erythrocyte shapes with such prevalent types as discocytes, spherocytes, and echinocytes were revealed in the blood of the patients. The surface of certain cells contained microvesicules. The spatial heterogeneity of the structure of mechanical property maps of the cell surface layer was detected. Conclusion. The diversity of erythrocyte features in patients with hereditary spherocytosis is present both at the level of the cell shapes and at the level of the structure of mechanical property maps of their surface layer.