Open AccessASSESSMENT OF THE POTENTIAL OF EXPERIMENTAL USE OF RATS TO STUDY THE CHONDROPROTECTIVE EFFICACY OF MEDICAL PRODUCTS FROM HUMAN BLOOD
Author(s) -
V. I. Nikolayev,
Д. А. Зиновкин,
А. А. Тretyakov
Publication year - 2018
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2018-15-2-14
Subject(s) - medicine , human blood , pathological , knee joint , articular cartilage , surgery , osteoarthritis , pathology , physiology , alternative medicine
Objective: to study the effect of human blood serum on the structure of the synovial environment of the rat`s joint. Material and methods. The experiment was performed on three groups of white laboratory rats, 12 in each group. All the animals were given injections of human blood serum into the left knee joint, and 0.9% NaCl into the right one (control). The animals of the first group were withdrawn from the experience one week after intra-articular injections, the second and third groups - also a week later, after two and three injections, respectively, the interval between the injections was one week. The histological examination of the knee joints of the rats was made according to the generally accepted procedure. Results. No pathological tissue reactions to the introduction of human blood serum into the joints of the rats have been detected. Conclusion. The obtained data indicate that blood serum has a pronounced regenerative potential in relation to cartilage tissue.