Open AccessTHE ASSESSMENT OF THE PROGNOSTIC SIGNIFICANCE OF THE LEVEL OF MATRIX METALLOPROTEINASE-2 EXPRESSION IN COLON CANCER
Author(s) -
Т. Т. Shtabinskaya,
Magdalena Bodnar,
S. А. Lyalikov,
V. A. Basinskiy,
А. . Маршалэк
Publication year - 2015
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2015-12-4-7
Subject(s) - colorectal cancer , immunohistochemistry , medicine , matrix metalloproteinase , clinical significance , metastasis , cancer , oncology , monoclonal antibody , metalloproteinase , pathology , antibody , immunology
The leading factors triggering neoangiogenesis include matrix metalloproteinases. Objective: to assess the prognostic significance of the level of MMP-2 expression in colon cancer. Material and methods. The clinical and morphological analysis of 72 cases of colorectal cancer resected over 2001-2011. Immunohistochemical studies using mouse monoclonal antibodies to MMP-2 were performed in the laboratory of Collegium Medicum Bydgoszcz. Results. The research showed a relation between the level of matrix metalloproteinase-2 expression in colon cancer to the age of the patients, level of differentiation, invasion and metastasis of cancer, and survival of patients. However, the data suggest there is no direct relation between an increase in the marker expression and tumor progression.