Open AccessEFFECTS OF DRUG SUBSTANCES FRUGLYUMIN A AND FRUGLYUMIN B ON T-CELL AND B-CELL-MEDIATED IMMUNE RESPONSE IN MICE IN NORMAL AND WITH IMMUNODEFICIENCY
Author(s) -
Svetlana Krivenko
Publication year - 2015
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2015-12-3-16
Subject(s) - immune system , b cell , immunology , antibody , spleen , polysaccharide , in vivo , immunodeficiency , immunity , humoral immunity , antigen , biology , t cell , antibody titer , cell , titer , biochemistry , microbiology and biotechnology
The results of investigation of immunomodulatory properties of the group-specific polysaccharides A and group-specific polysaccharides B, which are the substances of drugs Fruglyumin A and Fruglyumin B, are presented. It is found that in vivo the group-specific polysaccharides provide increased immunological response of T lymphocytes to the antigen in experimental animals with normal immune status and with secondary immunodeficiency. FA and FB do not possess immunostimulating effect on B-cell immunity in experimental animals with normal immune system reactivity. In mice with secondary immunodeficiency substances of group-specific polysaccharides ensure restoration of normal value of the spleen antibody-forming cells and antierythrocyte antibody titers, indicating stimulation of antibody formation function of B-lymphocytes.