Open AccessTHE TREATMENT FOR RELAPSED AND REFRACTORY FORMS OF ACUTE MYELOID LEUKEMIA
Author(s) -
Д. И. Суворов,
Н. Н. Климкович
Publication year - 2014
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2014-11-4-15
Subject(s) - myeloid leukemia , medicine , refractory (planetary science) , risk stratification , hematopoietic stem cell transplantation , oncology , transplantation , myeloid , disease , leukemia , acute leukemia , immunology , biology , astrobiology
The review focuses on relapse and refractory forms of acute myeloid leukemia, which is a heterogeneous disease and does not have a single universal therapeutic scheme. The paper presents the characteristics of protocols with inclusion of new agents, shows the role of allogenic hematopoietic stem cell transplantation and advances in risk stratification for the treatment for acute myeloid leukemia. The prospects of the therapy personalization based on molecular tests have been determined. The application of more effective induction and post-remission protocols shows a guaranteed reduction in the relapse rate.