Open AccessTHE STUDY OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN CHILDREN WITH UROPATHY OF THE UPPER URINARY TRACTS
Author(s) -
G.N. Drannik,
V. F. Peterburgskiy,
V. Driyanskaya,
Н. А. Калініна,
И. В. Багдасарова,
F. Z. Gayseniuk,
О. В. Лавренчук,
Т. В. Порошина,
N. A. Sevastyanova
Publication year - 2014
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2014-11-3-15
Subject(s) - obstructive uropathy , medicine , urinary system , urine , inflammation , cytokine , tumor necrosis factor alpha , proinflammatory cytokine , transforming growth factor , gastroenterology , urology
The purpose of the work is to study the role and significance of the research for pro- (TNF-α, IL-23, MCP-1) and anti-inflammatory (TGF-β) blood cytokines in blood and urine in children with uropathy of the upper urinary tracts (UUUT). Material and methods . 52 children with UUUT (1 group) and also 43 children free of UUUT with the infected urinary system (2 group) were examined. The immuno-enzymic method ELISA and the corresponding test-systems were used to study the levels of cytokines in blood and urine. Results. The analysis showed a significant increase in the levels of all the studied pro- (TNF-α, MCP-1, IL-23) and anti-inflammatory (TGF-β 1) cytokines in the blood of the patients in groups 1 and 2. The levels of TNF-α and TGF-β in urine are considered as diagnostic markers of inflammation and fibrosis, including the state after reconstructive surgery, and that of MCP-1 in blood - as acute aggravation of chronic pyelonephritis. Conclusion. The TNF-α and TGF-β levels in blood of the children with congenital uropathy can be additional diagnostic and prognostic markers and also in the dynamics of the treatment with nephroprotection.