Open AccessDRUGS AS INDUCERS OF STEVENS-JOHNSON SYNDROME - TOXIC EPIDERMAL NECROLYSIS IN CHILDREN
Author(s) -
T. P. Dyubkova,
В. Ф. Жерносек
Publication year - 2014
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2014-11-3-1
Subject(s) - toxic epidermal necrolysis , lamotrigine , phenobarbital , medicine , dermatology , incidence (geometry) , pharmacology , epilepsy , psychiatry , physics , optics
The review presents causes and clinical features of Stevens-Johnson syndrome, toxic epidermal necrolysis (SJS/TEN), in children and analyzes the role of drugs as inducers of the illness. The high risk of SJS/TEN in children is associated with co-trimoxazol (sulfamethoxazol + trimethoprim), other anti-infective sulfonamides, anticonvulsants (phenobarbital, carbamazepin, lamotrigine), non-steroidal anti-inflammatory drugs of the oxicam-type. The highest risk of SJS/TEN development occurs during the first eight weeks of treatment with a subsequent sharp decrease in the incidence rate. Certain genetic factors contribute to SJS/TEN development.