МARKERS OF INTRAVASCULAR INFLAMMATION AND CYTOKINE PROFILE IN ARTERIAL HYPERTENSION

The purpose of the research was to evaluate markers of intravascular inflammation and proinflammatory and anti-inflammatory cytokines in blood arterial hypertension (AH) patients. It was revealed, that the studied indices in patients with isolated AH I-II were within the values of healthy people. In AH with left ventricular hypertrophy, there was an increase in such markers as von Willebrand factor and soluble P-selectin, tumor necrosis factor α and IL-6, without any essential changes in highly-sensitive СRP and IL-1 levels. The patients had a decreased IL-10 level among anti-inflammatory cytokines. In AH with left ventricular hypertrophy and blood lymphocytosis, there was an increase in the soluble P-selectin level and von Willebrand factor, as well as in highly-sensitive СRP. That was accompanied by increased levels of tumor necrosis factorα, IL-1, IL-6, and IL-10. As for IL-4, no patients with AH revealed essential changes.