Open AccessEFFECT OF ANGIOTENSIN-CONVERTING ENZYME GENE I/D POLYMORPHISM ON NEPHROPATHY IN DIABETIC PATIENTS
Author(s) -
О. Н. Василькова,
А. Е. Силин,
В. Н. Мартинков,
I. B. Tropashko,
K. K. Zekenova,
M. V. Zhmailik,
Т. В. Мохорт
Publication year - 2014
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2014-11-2-7
Subject(s) - diabetic nephropathy , genotype , genotyping , angiotensin converting enzyme , medicine , allele , nephropathy , endocrinology , polymorphism (computer science) , diabetes mellitus , peptidyl dipeptidase a , gene , biology , genetics , blood pressure
Aim: to study the relation of angiotensin-converting enzyme ACE (I/D) in genetic susceptibility of diabetic nephropathy (DN). Methods. I/D polymorphism of ACE gene was studied in 58 patients with diabetes type 2. Results. There are no reliable differences in detection of DD genotype and D allele in patients with DN and without DN (40,9 and 52,3 %, 19,4 and 41,7 %, respectively) (p = 0,076, LR = 0,313, 95 % DI = 0,084-1,164 for DD and p = 0,266, LR = 0,631, 95 % DI = 0,303-1,312 for D). Conclusion. The comparison of the results of genotyping in patients with and without DN did not reveal any differences in distribution of allele and ACE genotypes.