Open AccessTHE EFFECT OF SURGICAL SUTURe MATERIAL MODIFIED WITH SILVER NANO-PARTICLES ON THE COURSE OF IMFLAMMATORY wound process <i>in vivo </i>IN microbial contamination
Author(s) -
B. O. Kabeshev,
Д. А. Зиновкин,
Д. Н. Бонцевич,
Э. А. Надыров
Publication year - 2014
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2014-11-2-23
Subject(s) - in vivo , connective tissue , wound healing , biomedical engineering , materials science , silver nanoparticle , polyamide , chemistry , surgery , nanoparticle , nanotechnology , medicine , pathology , composite material , biology , microbiology and biotechnology
The aim of the work was to study the effect of new polyamide-based antibacterial surgical sutural material modified with silver nano-particles and obtained by the method of metal and vapour synthesis on the course of inflammatory wound process in vivo. Material and methods. Polyamide threads produced by «Volot» (Russia), Specification 9432-001-24648800-95 and their analogs modified with silver nano-particles were used in the work. Sutural material was implanted into the back muscles of outbred female albino rats. Local inflammatory and tissue reaction was assessed in compliance with State Standard Specification P ISO 10993 «Medical Products. The assessment of the biological effect of medical products». Results. The research revealed earlier occurrence of the proliferative stage of inflammation when using a modified thread and formation of a well blood-supplied thin connective tissue capsule, which makes it possible to consider this as a precondition for wound healing by primary intention. Conclusion. The thread modified with silver nano-particles is more bioinert and causes less evident inflammatory response of the tissues to implantation.