Open AccessFREE AMINOACIDS OF BLOOD PLASMA AND SPLEEN IN ADMINISTRATION OF LEAD ACETATE AND AMINO ACID-MICROELEMENT COMPOSITION «TRITARG» INTO ANIMALS
Author(s) -
V. M. Sheibak,
A. Y. Pavliukovets,
V. Yu. Smirnov
Publication year - 2014
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2014-11-2-18
Subject(s) - taurine , amino acid , spleen , chemistry , methionine , glutamic acid , lead acetate , aromatic amino acids , metabolism , proline , blood plasma , biochemistry , medicine , toxicity , organic chemistry
Objective: to develop protective properties of the amino acid-microelement composition «Tritarg» in experimental lead intoxication. Material and Methods. The experiments were conducted on white female rats. Free amino acids were tested by the reversed-phase HPLC. Results. Lead intoxication leads to a significant increase of total free amino acids and their nitrogen-containing metabolites in rats` blood plasma. The concentration of glutamate and proline, as well as the relative amount of aromatic amino acids increase in the spleen. The introgastric administration of «Tritarg» into rats treated with lead acetate, increased the level of hyperaminoacidemia and also stimulated the release of amino acids into cells and, probably, their metabolism in the spleen. Conclusion. The ten-day introgastric administration of «Tritarg» into the rats treated with lead acetate increases mobilization of free amino acids, as well as methionine, cystathionine, taurine in the blood plasma and spleen.