Open AccessASSESSMENT OF EFFECTIVENESS OF FLUDARABINE-CONTAINING CHEMOTHERAPY PROGRAMS IN ONCOHEMATOLOGICAL PATIENTS
Author(s) -
Dmitry V. Kravchenko,
D. K. Novik
Publication year - 2014
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2014-11-2-11
Subject(s) - fludarabine , flag (linear algebra) , chemotherapy , medicine , oncology , complete remission , intensive care medicine , cyclophosphamide , mathematics , pure mathematics , algebra over a field
Purpose: to assess effectiveness of fludarabine-containing chemotherapy programs in treatment of oncohematological patients after relapse or in primary chemoresistance. Material and methods. Within 2006-2013, 11 patients with various oncohematologic disorders were treated using fludarabine-containing high-dose chemotherapy programs FLAG or FLAG-Ida at the Republican Research Center for Radiation Medicine and Human Ecology. Results. The best results of this pilot study were obtained in the chemotherapy program FLAG-Ida. Remission was achieved in younger patients, in contrast to the group of elderly patients with no remission. All the patients who achieved remission were female, and among the 7 patients, who did not achieve remission, more than half were men. Conclusion. Thus, on the whole the fludarabine-containing programs of chemotherapy are effective in the treatment for oncohematological pathology, but further research is needed to develop a more differentiated approach to the application of the programs to improve the effectiveness of the therapy of these diseases.