Open AccessHepatocytIC differentiation of mesenchymal stem cells (literature review)
Author(s) -
А. Г. Скуратов,
D. R. Petrenyov,
А. Н. Кондрачук
Publication year - 2013
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2013-10-1-5
Subject(s) - mesenchymal stem cell , mesenchyme , stem cell , transplantation , biology , medicine , bioinformatics , intensive care medicine , microbiology and biotechnology , surgery
The data of WHO indicate that liver diseases of different etiology are one of the 10 most frequent death causes in the world. Liver transplantation and use of its bioengineered analogs are limited by their high cost and adverse effects of the treatment, as well as by limited availability of donor organs and functional cellular elements. The application of innovative approaches of directed differentiation of mesenchyme stem cells can help overcome the shortcomings of current treatment methods. The present literature review covers the main sources, particularities of differentiation and safety aspects of the application of mesenchymal stem cell in the treatment of hepatic failure.