Open AccessPHARMACOLOGICAL EFFECT OF THE COMBINED APPLICATION OF CANDESARTAN AND RESVERATROL
Author(s) -
A. Beliayeva,
I. S. Dorofeyenko,
A. K. Vlasenko,
V. B. Sazanov,
V. Yu. Afonin
Publication year - 2013
Publication title -
problemy zdorovʹâ i èkologii
Language(s) - English
Resource type - Journals
eISSN - 2708-6011
pISSN - 2220-0967
DOI - 10.51523/2708-6011.2013-10-1-13
Subject(s) - candesartan , resveratrol , pharmacology , stimulation , flow cytometry , chemistry , bone marrow , medicine , endocrinology , receptor , angiotensin ii , biochemistry , immunology
Objectives: to analyze the number of stem cells in bone marrow and peripheral blood of mice, locomotor activity and heart weight of the animals in administration of resveratrol and candesartan cilexetil in different dosages and combinations. Materials and methods. Male C57Bl/6 mice and male Balb/C mice were used. Locomotor activity was studied using the «Opto-Varimex» measurements. We investigated the number of stem cells with CD117 phenotype (flow cytometry). Statistical analysis of the data was performed using Excel. Results. Candesartan reduces the locomotor activity of mice. The estimated parameters of motor activity corresponded to those of the control group in the combined introduction of sartan and resveratrol. Candesartan at a dose of 3 mg/kg and its complex with resveratrol at 10 mg/kg dose and at 50 mg/kg dose stimulate the formation of cells with CD117. Conclusion. The combination of the studied drugs is safe and effective in relation to the stimulation of stem cells formation in comparison with the monopreparation candesartan cilexetil.