Open AccessHistopathological Type of Lung Cancer and Underlying Driver Mutations in Patients with Chronic Obstructive Pulmonary Disease (COPD) versus Patients with Asthma and COPD Overlap: A Single-Center Retrospective Study
Author(s) -
Tamami Sakai,
Johsuke Hara,
Kenta Yamamura,
Masahiro Abo,
Akihito Okazaki,
Noriyuki Ohkura,
Kazuo Kondo
Publication year - 2020
Publication title -
turkish thoracic journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 7
ISSN - 2149-2530
DOI - 10.5152/turkthoracj.2019.18100
Subject(s) - copd , lung cancer , medicine , epidermal growth factor receptor , lung , obstructive lung disease , oncology , anaplastic lymphoma kinase , gastroenterology , retrospective cohort study , cancer , single center , pathology , malignant pleural effusion
Chronic obstructive pulmonary disease (COPD) increases the risk of lung cancer. The relationships between COPD and Asthma COPD Overlap (ACO), and between the histopathological types of lung cancer and driver mutations remain unclear and need further study. The aim of this retrospective study was to examine the relationships between the histopathological type, frequency of epidermal growth factor receptor (EGFR) driver mutations, and anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements in the lung cancers of patients with COPD and ACO.