Open AccessThe Epstein criteria predict for organ-confined prostate cancer but not for minimal residual disease and outcome after radical prostatectomy
Author(s) -
Nigel P Murray,
Cynthia Fuentealba,
Eduardo Reyes,
Aníbal Salazar,
Eghon Guzmán,
Shenda Orrego
Publication year - 2020
Publication title -
turkish journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.347
H-Index - 8
eISSN - 2149-3057
pISSN - 2149-3235
DOI - 10.5152/tud.2020.20147
Subject(s) - prostatectomy , micrometastasis , medicine , prostate cancer , hazard ratio , oncology , disease , minimal residual disease , surgery , cancer , bone marrow , gynecology , metastasis , confidence interval
The Epstein criteria (EC) used to select men for active surveillance do not predict biologically insignificant diseases. Minimal residual disease (MRD) is an undetected microscopic disease that remains after radical prostectomy (RP) and is a biological classification associated with the risk of treatment failure. Subtypes of MRD, the 10-year biochemical failure free survival (BFFS), and restricted mean biochemical failure free survival time (RMST) were determined and compared in EC patients treated with RP.