Open AccessAre cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature
Author(s) -
Özgür Mehtap,
Elif Birtaş Ateşoğlu,
Emel Gönüllü,
Hakan Keski,
Abdullah Hacıhanefioğlu
Publication year - 2011
Publication title -
turkish journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.351
H-Index - 16
ISSN - 1300-7777
DOI - 10.5152/tjh.2011.32
Subject(s) - medicine , lymphoblastic leukemia , myeloid leukemia , leukemia , nuclear medicine , gynecology
Cup-like morphology is defined as cup-like nuclear invagination spanning ≥25% of the nuclear diameter in >10% of blasts. Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia (AML) patients. Herein we describe a patient with cup-like blasts that was diagnosed and treated for common acute lymphoblastic leukemia (ALL). In contrast to the literature, the presented case was Philadelphia chromosome positive and FLT3 ITD negative.