Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature | Zendy

Özgür Mehtap | Zendy; Elif Birtaş Ateşoğlu | Zendy; Emel Gönüllü | Zendy; Hakan Keski | Zendy; Abdullah Hacıhanefioğlu | Zendy

Open Access

Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature

Author(s) -

Özgür Mehtap,

Elif Birtaş Ateşoğlu,

Emel Gönüllü,

Hakan Keski,

Abdullah Hacıhanefioğlu

Publication year - 2011

Publication title -

turkish journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.351

H-Index - 16

ISSN - 1300-7777

DOI - 10.5152/tjh.2011.32

Subject(s) - medicine , lymphoblastic leukemia , myeloid leukemia , leukemia , nuclear medicine , gynecology

Cup-like morphology is defined as cup-like nuclear invagination spanning ≥25% of the nuclear diameter in >10% of blasts. Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia (AML) patients. Herein we describe a patient with cup-like blasts that was diagnosed and treated for common acute lymphoblastic leukemia (ALL). In contrast to the literature, the presented case was Philadelphia chromosome positive and FLT3 ITD negative.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research