Open AccessEffects of Probiotic Bacteria on Central Neuronal Activation in Experimental Colitis
Author(s) -
Neriman Şengül,
AUTHOR_ID,
Fatma Töre,
Sevil Işık,
Belma Aslım,
Gülberk Uçar,
Tülin Fırat,
Samiye Yabanoğlu Çiftçi,
Aysel Kükner,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2022
Publication title -
pubmed central
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 28
eISSN - 2148-5607
DOI - 10.5152/tjg.2022.201175
Subject(s) - colitis , probiotic , inflammatory bowel disease , medicine , inflammation , oxidative stress , immunology , endocrinology , biology , bacteria , disease , genetics
Brain-gut axis dysregulation is observed in inflammatory bowel disease. However, the effect of altered gut flora on neuro- immunomodulation and its role in the pathogenesis of inflammatory bowel disease are unknown. The aims of this study are to determine (i) whether colitis modifies the expression of c-fos, a marker of general neuronal activation in the brain and (ii) whether this activation could be modulated by probiotic bacteria.