Open AccessFragmentation Analysis of Plasma DNA Reveals Its Prognostic Value in Gastric Cancer
Author(s) -
Ebru Esin Yörüker,
Emre Özgür,
Metin Keskin,
İlker Özgür,
Uğur Gezer
Publication year - 2021
Publication title -
pubmed central
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 28
eISSN - 2148-5607
DOI - 10.5152/tjg.2021.20832
Subject(s) - medicine , fragmentation (computing) , cell free fetal dna , dna fragmentation , gastroenterology , cancer , oncology , pathology , apoptosis , programmed cell death , biology , genetics , pregnancy , ecology , fetus , prenatal diagnosis
Gastric cancer (GC) is a common cause of cancer-related deaths. The poor clinical outcome in GC patients is partially associated with a lack of appropriate diagnostic and prognostic biomarkers. In the present study, we evaluated the diagnostic and prognostic values of cell-free DNA (cfDNA) integrity and the concentration of circulating nucleosomes (cNUCs).