Investigation of Dynamic Thiol/Disulfide Homeostasis and Nitrosative Stress in Patients with Wilson Disease | Zendy

Emine Melis Yücel | Zendy; Buğra Tolga Konduk | Zendy; Ahmet Saracaloğlu | Zendy; Sezgin Barutçu | Zendy; Şeniz Demiryürek | Zendy; Fatma Kaba | Zendy; Belma Doğan Güngen | Zendy; Abdullah T. Demiryürek | Zendy

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Investigation of Dynamic Thiol/Disulfide Homeostasis and Nitrosative Stress in Patients with Wilson Disease

Author(s) -

Emine Melis Yücel,

Buğra Tolga Konduk,

Ahmet Saracaloğlu,

Sezgin Barutçu,

Şeniz Demiryürek,

Fatma Kaba,

Belma Doğan Güngen,

Abdullah T. Demiryürek

Publication year - 2021

Publication title -

the turkish journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.404

H-Index - 28

eISSN - 2148-5607

pISSN - 1300-4948

DOI - 10.5152/tjg.2021.20549

Subject(s) - thiol , oxidative stress , homeostasis , nitric oxide , medicine , disulfide bond , pathogenesis , disease , wilson's disease , endocrinology , biochemistry , chemistry

Wilson disease (WD) is an autosomal recessive inherited disorder of copper (Cu2+) metabolism, resulting in Cu2+ accumulation and liver and central nervous system toxicity. Oxidative stress may have a role in the pathogenesis of Wilson disease, but the roles of thiol/disulfide homeostasis and nitrosative stress have not been examined. The purpose of this study was to evaluate whether there is a modification in thiol/disulfide homeostasis and nitrosative stress in patients with Wilson disease.

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