Open AccessInvestigation of Dynamic Thiol/Disulfide Homeostasis and Nitrosative Stress in Patients with Wilson Disease
Author(s) -
Emine Melis Yucel,
Buğra Tolga Konduk,
Ahmet Saracaloğlu,
Sezgin Barutçu,
Şeniz Demiryürek,
Fatma Kaba,
Belma Doğan Güngen,
Abdullah Tuncay Demiryürek
Publication year - 2021
Publication title -
pubmed central
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 28
eISSN - 2148-5607
DOI - 10.5152/tjg.2021.20549
Subject(s) - thiol , oxidative stress , homeostasis , medicine , nitric oxide , wilson's disease , disulfide bond , pathogenesis , disease , endocrinology , biochemistry , chemistry
Wilson disease (WD) is an autosomal recessive inherited disorder of copper (Cu2+) metabolism, resulting in Cu2+ accumulation and liver and central nervous system toxicity. Oxidative stress may have a role in the pathogenesis of Wilson disease, but the roles of thiol/disulfide homeostasis and nitrosative stress have not been examined. The purpose of this study was to evaluate whether there is a modification in thiol/disulfide homeostasis and nitrosative stress in patients with Wilson disease.