Open AccessAssessment of the Relationship between Ulcerative Colitis and Forkhead Box P3 Polymorphisms
Author(s) -
Yakup Ülger,
Ersin Akgöllü
Publication year - 2021
Publication title -
the turkish journal of gastroenterology/the turkish journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 28
eISSN - 2148-5607
pISSN - 1300-4948
DOI - 10.5152/tjg.2020.20478
Subject(s) - ulcerative colitis , medicine , foxp3 , allele , immunology , colitis , inflammatory bowel disease , inflammation , population , gastroenterology , disease , immune system , gene , genetics , biology , environmental health
Ulcerative colitis (UC) is a chronic disease that does not have a definitive treatment and causes repetitive inflammation of the colon and impaired quality of life. The FOXP3 gene codes FOXP3 protein responsible for development and function of regulatory T (Treg) cells. The rs2232365 A/G and the rs3761548 A/C polymorphisms of FOXP3 gene were indicated to be associated with inflammation-related diseases such as ulcerative colitis. The effectiveness of Treg cells, which act as immune-suppressors in the control of inflammation, can be affected by these polymorphisms. The aim of the present study was to evaluate the association between these polymorphisms with ulcerative colitis.