Open AccessDetermination of B- and T- cell epitopes for Helicobacter pylori cagPAI: An in silico approach
Author(s) -
Sevgi Kalkanlı Taş,
Duygu Kırkık,
Kübra Öztürk,
Alpaslan Tanoğlu
Publication year - 2020
Publication title -
the turkish journal of gastroenterology/the turkish journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 28
eISSN - 2148-5607
pISSN - 1300-4948
DOI - 10.5152/tjg.2020.19154
Subject(s) - helicobacter pylori , epitope , in silico , gastritis , pathogenicity island , pathogenicity , genbank , microbiology and biotechnology , medicine , biology , antigen , gene , immunology , genetics , virulence
Helicobacter pylori is classified as a gram-negative bacteria and can cause significant diseases, including gastric cancer, mucosa-associated lymphoid tumor, peptic ulcer, and chronic gastritis. Recent studies have shown that some autoimmune diseases are also associated with H. pylori. In the past decades, polymorphisms of certain genes of H. pylori, mechanisms and strains of H. pylori, and new therapeutic approaches have continued to be defined. Bioinformatic tools continue to be used in drug design and vaccine design. This study aimed to investigate the cag pathogenicity island (cagPAI) of H. pylori using an in silico approach, which could contribute to vaccine studies.