Open AccessBone marrow mesenchymal stem cells differentiate into intestinal epithelioid cells through the ERK1/2 pathway
Author(s) -
Ting Jiang,
Meng-Lin Shi,
Geng Xia,
Yina Yang,
Jiamin Xu,
Yun-Jie Lei,
Yanyan Tang,
Jinhui Yang
Publication year - 2020
Publication title -
the turkish journal of gastroenterology/the turkish journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 28
eISSN - 2148-5607
pISSN - 1300-4948
DOI - 10.5152/tjg.2020.18644
Subject(s) - mesenchymal stem cell , microbiology and biotechnology , stem cell , enterocyte , signal transduction , protein kinase a , kinase , western blot , cellular differentiation , medicine , cancer research , biology , small intestine , biochemistry , gene
Previous studies have found that the injection of rat bone marrow mesenchymal stem cells (rBMSCs) in a mouse model of acute hepatic failure significantly relieves intestinal damage and endotoxemia. However, the mechanism of this process remains unknown. This study demonstrated the differentiation of rBMSCs into enterocyte-like cells and possible molecular mechanisms for this with the aim of finding a new treatment for intestinal epithelial injury and endotoxemia during liver failure.