Open AccessInterferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population
Author(s) -
Zahra Heidari,
Bita Moudi,
Hamidreza MahmoudzadehSagheb
Publication year - 2020
Publication title -
the turkish journal of gastroenterology/the turkish journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 28
eISSN - 2148-5607
pISSN - 1300-4948
DOI - 10.5152/tjg.2020.181024
Subject(s) - single nucleotide polymorphism , medicine , genotype , allele , hepatitis b , immunology , snp , interferon , interferon gamma , allele frequency , virology , population , gene , cytokine , biology , genetics , environmental health
Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-γ and IFN-γR1 genes may influence the susceptibility to HBV. Here, we evaluated the impact of interferon gamma (+874 T/A) and its receptor (-611A/G, +189G/C and +95C/T) polymorphisms and the risk of HBV in Iranian patients.