Open AccessBRCA1 and BRCA2 sequence variations detected with next-generation sequencing in patients with premature ovarian insufficiency
Author(s) -
Nafiye Yılmaz,
Peren Hatice Karagin,
Yunus Kasım Terzi,
Serkan Kahyaoğlu,
Saynur Yılmaz,
Salım Erkaya,
Feride İffet Şahin
Publication year - 2016
Publication title -
journal of the turkish-german gynecological association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.346
H-Index - 16
eISSN - 1309-0399
pISSN - 1309-0380
DOI - 10.5152/jtgga.2016.16035
Subject(s) - premature ovarian insufficiency , premature ovarian failure , ovarian cancer , etiology , mutation , biology , medicine , oncology , gene , bioinformatics , genetics , cancer
Although the association between BRCA1 and BRCA2 gene mutations and breast and ovarian cancer is known, there is insufficient data about premature ovarian insufficiency (POI). However, several studies have reported that there might be a relationship between POI and BRCA1 and BRCA2 gene mutation. Therefore, in the present study, we aimed to investigate the role of BRCA1 and BRCA2 gene mutations in the etiology of POI in a Turkish population.