Open AccessHOXA11 and MMP2 gene expression in uterosacral ligaments of women with pelvic organ prolapse
Author(s) -
Nafiye Yılmaz,
Gülnur Özakşit,
Yunus Kasım Terzi,
Saynur Yılmaz,
Burcu Budak,
Orhan Aksakal,
Feride İffet Şahin
Publication year - 2014
Publication title -
journal of the turkish-german gynecological association
Language(s) - English
Resource type - Journals
eISSN - 1309-0399
pISSN - 1309-0380
DOI - 10.5152/jtgga.2014.0088
Subject(s) - uterosacral ligament , mmp2 , medicine , gynecology , urology , gene expression , andrology , metastasis , surgery , gene , biology , vagina , cancer , biochemistry
Pelvic organ prolapse (POP) is a common disorder that negatively impacts the quality of life in many women. Uterosacral ligaments (USLs) are supportive structures of the pelvic organs that are often attenuated in women with POP. The HOXA genes regulate the development of the uterosacral ligaments. We compared expression of HOXA11 and MMP2 in USLs of women with and without POP.