Open AccessBone marrow involvement: Atypical presentation of early-onset childhood sarcoidosis
Author(s) -
Rajkumar M. Meshram,
Vishal S Gajimwar,
Siddhant Gholap,
Madhuri Jhanwar
Publication year - 2020
Publication title -
european journal of rheumatology :/european journal of rheumatology
Language(s) - English
Resource type - Journals
eISSN - 2147-9720
pISSN - 2148-4279
DOI - 10.5152/eurjrheum.2020.20076
Subject(s) - sarcoidosis , medicine , bone marrow , rash , pathology , giant cell , prednisolone , uveitis , etiology , arthritis , dermatology , immunology , gastroenterology
Childhood sarcoidosis is a chronic multisystemic, non-caseating granulomatous disease of unknown etiology. Early-onset disease classically presents with a triad of skin rash, uveitis, and arthritis, but bone marrow involvement is rare. We report a 9-1/2-year old Indian female child who presented with bleeding manifestation, skin rash, uveitis, and arthritis. Bone marrow biopsy showed multiple non-necrotizing granulomas comprising epithelioid cells, mature lymphocytes, and multinucleated giant cells with few eosinophils in the background, with negative staining for acid-fast bacilli or fungi. She was treated successfully with oral prednisolone. This is the first report of an early-onset childhood sarcoidosis with bone marrow involvement from India.