Open AccessAbsence of GATA4 Mutations in Moroccan Patients with Atrial Septal Defect (ASD) Provides Further Evidence of Limited Involvement of GATA4 in Major Congenital Heart Defects
Author(s) -
Ihssane El Bouchikhi,
Laila Bouguenouch,
Fatima Zohra Moufid,
Khadija Belhassan,
Imane Samri,
Amal Chaouti,
Mohammed Iraqui Houssaïni,
S. Atmani,
Karim Ouldim
Publication year - 2020
Publication title -
the eurasian journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.337
H-Index - 13
eISSN - 1308-8742
pISSN - 1308-8734
DOI - 10.5152/eurasianjmed.2020.19237
Subject(s) - medicine , tetralogy of fallot , gata4 , mutation , myh7 , genetics , mutation rate , atrioventricular septal defect , cardiology , bioinformatics , heart disease , gene , biology , gene expression , gene isoform
Atrial septal defect (ASD) is one of the most common types of congenital heart disease (CHD). It is mainly caused by mutations of NK2 homeobox 5, GATA binding protein 4 (GATA4), and myosin heavy chain 6 in non-syndromic cases. This study aims to carry out, for the first time, the GATA4 mutation screening in a Moroccan population affected by ASD and compare the obtained mutation rate across populations.