Open AccessCirculatory Levels of C-X-C Motif Chemokine Ligands 1, 9, and 10 Are Elevated in Patients with Ischemic Stroke
Author(s) -
Masoud Amin,
Alireza Vakilian,
Mohammad Hossein Mahmoodi,
Gholamhossein Hassanshahi,
Soudeh Khanamani Falahati-Pour,
Maryam Rafiei Dolatabadi,
Ali Esmaeili Nadimi
Publication year - 2017
Publication title -
the eurasian journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.337
H-Index - 13
eISSN - 1308-8742
pISSN - 1308-8734
DOI - 10.5152/eurasianjmed.2017.17022
Subject(s) - medicine , chemokine , cxcl9 , cxcl10 , cxc chemokine receptors , cxcl1 , stroke (engine) , ischemic stroke , immunology , inflammation , chemokine receptor , ischemia , mechanical engineering , engineering
Inflammation plays a significant role in the development of ischemic stroke. CXC chemokines play pleiotropic roles in prolonged leukocyte locomotion, astrocyte migration/activation, and neural attachment/sprouting in response to focal stroke. In this study, we aimed to explore the changes in serum levels of three chemokines, C-X-C motif chemokine ligand 1 (CXCL1), C-X-C motif chemokine ligand 9 (CXCL9), and C-X-C motif chemokine ligand 10 (CXCL10), in ischemic stroke patients at the time of admission and before discharge from the hospital ward.